HomeAIDS Applications 》Facing AIDS with Hope
Monitoring Disease Progression; Regaining Hope for Life
Earvin "Magic" Johnson, Jr., one of the most successful basketball player in NBA history, was infected with HIV in 1991. Now 17 years has passed since he was infected, he is still healthy and living a normal life. This is all due to the fact that he has his CD4 level monitored every 3 months and has it kept in a normal range.

A large number of scientific research proves that: as long as there is a way to monitor and regulate CD4 level in a certain range, people infected with HIV can coexist peacefully with the viruses and live a normal life.
 
Bottleneck for the treatment of HIV
In human immunodeficiency virus (HIV) infection, accurate and reliable CD4 count is the most important marker of disease state and a key indicator for initiation and monitoring of ART and a measure of the effectiveness of the treatment. WHO, European and American countries all recommend that HIV carriers should have their CD4 level measured every 3-6 months, and the CD4 level could be used as an indicator for initiating antiretroviral therapy against opportunistic infections.

Today, the CD4-count is usually performed with flow cytometry, which is considered as the standard "Gold" reference method. However, the initial and maintenance costs of flow cytometer are relatively high, the reagents costs for each test are also high and the use of the instrument requires well trained operators. All these facts make the method inappropriate for routine analysis in many developing and resource-scarce countries.

Therefore, CD4 cell test has become the bottleneck and major focus for managing AIDS prevention and treatment globally.
 
Global Initiative
It is estimated that no less than 40 million people are living with HIV/AIDS worldwide, and the number of people living with the virus goes up at an accelerated rate, which poses a great challenge for the treatment and prevention of HIV/AIDS.

In 2006, Bill & Melinda Gates Foundation set up a special fund in Imperial College London, planning to invest $ 8.6 million to develop a simple, affordable, rapid and reliable test to measure CD4 cell count within 4 years.


In the same year, SemiBio's "CD4 Cell Count Chip" was already successfully developed. With features that can meet the 3 features and the 13 target specifications proposed by the Gates Foundation, the product can now be mass produced, a good 4 year ahead of what Gates Foundation has expected.
 

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